The majority of the collection is made up of miscellaneous subject files, which follow Dr. Rosen's detailed research, colleagues, and projects. In addition to the subject files, four series of special subject files, denoting those of particular importance, have been created for subjects containing multiple files.

The collection also contains files on the publications of Dr. Rosen, in addition to a number of books either written or contributed to by Rosen. The Presentations and Audio-Visual Materials series archive the many lectures given by Dr. Rosen at Texas A&M University and around the world. Four of the cassettes in the Audio Visual Materials Series record interviews with survivors of suicide attempts from the Golden Gate Bridge. One film reel, Discussion with Dr. Carl Jung, is in a degraded condition and stored in the film vault.

As Dr. Rosen focused most of his work on Analytical or Jungian Psychology, the majority of his collection is dedicated to his research, publications, and lectures given on the subject.